Reasons why a hamster may not use the running wheel may include:
Unfamiliar environment: When a hamster first enters a new environment, it is not yet familiar enough with the surroundings, so it will not use the running wheel for the time being.

Unsuitable running wheel: The running wheel may be too small, too rough, or too noisy, causing the hamster to be reluctant to use it.
The hamster's personality: Some hamsters are naturally more "homebody" and too lazy to move.
Methods to solve the problem of a hamster not using the running wheel include:
Guiding and encouraging: You can tempt the hamster with food to let them gradually get used to running on the running wheel. For example, put some food that the hamster likes on the running wheel, or gently place the hamster on the running wheel and give encouragement.
Increasing the fun: Replace the running wheel with a brightly colored one or add some small decorations to make the running wheel more attractive to the hamster.
Checking and repairing the running wheel: If the running wheel is rusty or not running smoothly, you can try lubricating it with lubricating oil, or replace it with a new running wheel.
Providing alternatives: If there is no suitable running wheel, you can lay pipes, running discs and other alternatives to allow the hamster to have other ways of exercising.
The possible consequences of a hamster not using the running wheel may include:
Weight gain: Lack of exercise will lead to weight gain in the hamster, which in turn increases the risk of obesity-related diseases such as diabetes and heart diseases.
Anxiety: Lack of exercise can trigger anxiety in the hamster, and it may exhibit abnormal behaviors such as biting the cage and self-harm.